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Regarding the suggestion for a voluntary opt-in, we did not propose or consider a voluntary opt-in for certain types of ASM participants in the CY 2026 PFS proposed rule, so we believe these comments are out of scope

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One proposal is that hypofunction of NMDA receptors (NMDAR) located on inhibitory GABA inter-neurons leads to reduced activity of these inter-neurons, resulting in increased pyramidal glutamatergic neurotransmission and the diverse symptoms occurring in acute psychosis [3]

June 2026: Sandoz announced a targeted end-of-June 2026 launch of unbranded generic semaglutide in Canada, projecting a 60% to 70% price reduction relative to branded Ozempic, the entry is the first generic semaglutide launch in a Western high-income market and establishes a pricing reference case for subsequent launches in Brazil, Mexico, and Turkey