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Methods: We conducted a detailed analysis of preclinical data sets, Phase IIII clinical trials, regulatory documents, and pharmaco-epidemiological studies published between 2008 and 2025
Moreover, recent studies suggest that the induction of cellular senescence, rather than the promotion of apoptosis through radiotherapy or chemotherapy, might be the main mechanism for impairing the self-renewal capacity of cancer cells, particularly in the context of solid tumors [55]
Similar results were observed in 13 other children with ALL treated with zinc adjuvant therapy, suggesting that zinc adjuvant therapy may be important in the rapid and durable remission of pediatric ALL patients and warrants further study ( Due to the important role of selenocysteine in leukemogenesis found in studies at the cellular and animal levels, a clinical study by Weisberger et al