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In one aspect of the first embodiment of the present invention, the conversion of His- Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu- Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-Resin (wherein the amino acids of the sequence are optionally protected with protecting group(s)) to Semaglutide is carried out by cleavage of the peptide chain from the Resin and deprotection of all the amino acids wherever applicable by using cocktail mixture/cleaving reagent and reacting the obtained compound with compound of formula-3 in a solvent optionally in presence of a base and/or a coupling agent

Ozempic targets type 2 diabetes, whereas Wegovy is specifically for weight management

therefore, the concentration was too low for XRPD

In order to improve the oral availability of preparations, pH modification is a good method in practical application [196]

B vitamins are particularly important in patients receiving parenteral nutrition, where oral intake may be inadequate or unavailable