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As resident cells in intestinal crypts, Paneth cells (PCs) are essential for host defense by phagocytosing microorganisms, secreting antimicrobial peptides, and regulating the growth of enteric bacteria

[53] conducted a study to assess the radioprotective effects of alpha-tocopherol acetate (TA), ascorbic acid (AA), or a combination of these agents in rats

In contrast, most rat strains develop very limited injury even with much higher doses than used in mice [124]

Zhang J, Zhang M, Tatar M, Gong R