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A case-control study involving 55 patients with dry or wet AMD who received 3 mg of melatonin per night and were followed for more than six months found that visual acuity was generally stable and pathologic macular changes were reduced in the majority of participants (Yi 2005)

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Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met

47,75,76,77 Recently, we reported that GH promotes radioresistance in cancer cell lines 78 and that pegvisomant suppresses endometrial tumor regrowth following radiotherapy in a xenograft model, which highlights the potential utility of this combinational approach and identifies GHR antagonism as a potential molecularly targeted radiosensitizing strategy