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The process is thought to be associated with: Vascular Endothelial Growth Factor (VEGF) Nitric oxide signaling Endothelial cell migration Remodeling of extracellular matrix All of these processes are vital for our body since they affect oxygen delivery and tissue maintenance

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Pre-existing inborn errors of sulfur-amino-acid metabolism (e.g., homocystinuria) represent an absolute contraindication because parenteral methionine can exacerbate elevated homocysteine concentrations and associated thrombotic risk