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One of the most frequently discussed concerns is related to skin whitening a desired outcome for many, but also a controversial one when pursued aggressively without clinical oversight

Often, this feeling comes with sweating, as if the body's internal thermostat is set too high

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For instance, the pathogenic V122I variant of the protein transthyretin can induce cardiomyopathy due to destabilization of the transthyretin quaternary structure, i.e., the tetramer-folded monomer equilibrium, and an increased rate of tetramer dissociation [73]

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