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These feeding experiments were performed using a crossover design with 23 days apart between experimental days

The pathophysiology of IC/BPS is poorly understood, and theories include chronic inflammation, autoimmune dysregulation, bacterial cystitis, urothelial dysfunction, deficiency of the glycosaminoglycan (GAG) barrier and urine cytotoxicity

Though these findings stem from overseas imaging networks, they carry significant implications for patients and healthcare professionals

The risk of hypoglycemia with this combination is small

It should however be pointed out that the spray positioning strategies proposed in this study could be conjectured to be generic and should maximize drug delivery to the OMC and the sinuses for other sprays as well