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To confirm this hypothesis, in a rat model with diabetes (but without obesity), surgical diversion of the proximal intestine caused a rapid improvement in glycemia without a reduction in food intake or weight change [93]

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doi: 10.3389/fendo.2025.1587891 Received 05 March 2025 Accepted 24 June 2025 Published 16 July 2025 Volume 16 - 2025 Edited by Lawrence Merle Nelson, Mary Elizabeth Conover Foundation, Inc., United States Reviewed by Roger Smith, The University of Newcastle, Australia Qinqin Gao, First Hospital of Soochow University, China Updates Copyright 2025 Anti, Gheorghe, Deming, Adeoye, Zhang and Mata-Greenwood

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The manufacturer is shifting focus to this updated formulation rather than continuing Rybelsus