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Similar content being viewed by others Introduction Sickle cell disease (SCD) is an inherited hematological disorder caused by an A to T mutation in the adult -globin gene with the product of hemoglobin S which polymerizes under hypoxia conditions 1,2

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Acta Physiol 219:669682 Glaesner W, Vick AM, Millican R, Ellis B, Tschang SH, Tian Y, Bokvist K, Brenner M, Koester A, Porksen N, Etgen G, Bumol T (2010) Engineering and characterization of the long-acting glucagon-like peptide-1 analogue LY2189265, an Fc fusion protein

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