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Trials show ~1015% average body-weight loss

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Currently, there is no robust evidence to suggest that GLP-1 receptor agonists directly impair thermoregulation through pharmacological action on temperature control centres in the hypothalamus

In addition, Fer-1 alleviated DN and ameliorated renal hypertrophy and albuminuria by inhibiting ferroptosis, and ultimately reduced the accumulation of intracranial lipid peroxides in diabetic mice through the HIF-1/HO-1 pathway [242]