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3 Redox-sensitive proteins: gatekeepers of cellular signaling and homeostasis Several intracellular proteins function as redox sensors, undergoing reversible modifications that enable them to alternate between active and inactive conformations

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Their organization into broad categories represents an interconnected hierarchy where the primary hallmarks reflect macromolecular damage (i.e., genome, proteome, organelles) which lead to antagonistic hallmarks, e.g., response to the damage