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This monitoring period also gives them the chance to tweak the plan if necessary or introduce alternative medications, such as metformin, to maintain metabolic stability

Retatrutide and Weight Loss: What the Trial Data Shows In the NEJM 2023 phase 2 trial, participants at the highest retatrutide dose lost an average of approximately 24.2% of body weight at 48 weeks

Study Design This was an open-label, multicenter, randomized, prospective study conducted at Showa University Hospital, a private university hospital responsible for tertiary care, and Tokatsu Hospital, a general hospital providing secondary care, in Japan between April 2021 and May 2022

Surgeons typically recommend that patients maintain a stable weight for at least three to six months before undergoing the procedure