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One proposed mechanism involves adenylyl cyclase activity, which could raise cyclic AMP (cAMP) levels and activate protein kinase A (PKA)

Glutathione is the body's most powerful antioxidant, essential for detoxification, cellular protection, and slowing the aging process

Disadvantages, compared to sitagliptin, include an injectable dosage form and gastrointestinal side effects

DPP-4 inhibition with alogliptin on top of angiotensin II type 1 receptor blockade ameliorates albuminuria via up-regulation of SDF-1a in type 2 diabetic patients with incipient nephropathy

Deuterium labeled compound syntheses and LC/MS/MS quantification of trimethylamines Detailed descriptions of syntheses, isolation and characterization of all compounds are described under Supplemental Methods