Serious side effects include an increased risk of thyroid tumors, pancreatitis, and low blood sugar
Novel anti-diabetic drugs such as glucagon-like peptide-1 (GLP-1) receptor agonists, sodium glucose co-transporter 2 inhibitors and dipeptidyl peptidase 4 (DPP-4) inhibitors have demonstrated some protective effects against ocular conditions, including glaucoma
During World War II when the drug was used to treat malaria among troops fighting in the Pacific, it was noticed that servicemen with autoimmune conditions including inflammatory arthritis who took quinacrine or chloroquine experienced improvement
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However, they led to treatment discontinuation in a proportion of trial participants