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In STEP trials, fewer than 5% of patients randomized to tirzepatide 2.4 mg experienced weight gain, while discontinuation rates were 23%

Some patients may achieve their desired weight loss within a few months, while others may require longer-term management to maintain weight loss and prevent regain

In order to test the reactivity of the warheads against a thiol-surrogate, we executed an HPLC-based aqueous stability and a kinetic l-glutathione (GSH) reactivity assay 18,37

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