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Subsequently, the erythroid hematopoietic progenitor cells differentiate into the stages of proerythrocytes, early erythroblasts, intermediate erythroblasts, late erythroblasts, and reticulocytes

Accumulation of organic and inorganic peroxides in the blood of those patients plays a pivotal role in the depletion of erythrocyte GPx activity [78], which is further aggravated by deficiency of micronutrient antioxidants in the blood of those patients [56,57]

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More serious risks include pancreatitis, gallbladder disease, acute kidney injury with dehydration, suicidal ideation, and potential thyroid C-cell tumors (observed in rodent studies, though human relevance remains uncertain)