Under these conditions, the lyophilized material remains stable for several years
As an important channel of essential oxygen and energy sources for the brain, cerebral microvessels are an important component of the bloodbrain barrier (BBB), and its disruption is an early pathophysiological mechanism in neurodegenerative diseases (20)
Excess soft tissue in the airway, increased neck circumference, and reduced lung volume due to fat deposits in the abdomen all contribute to the severity of OSA in individuals with obesity
Exclusion criteria were similar across trials and those with recent cardiovascular events or heart failure (NYHA class IV), history of acute or chronic pancreatitis, impaired renal function, or any chronic disorder or severe disease that might jeopardize patients safety or compliance with the protocol, were not eligible for enrolment
By elucidating how these systemic metabolic disturbances converge to induce selective ferroptotic damage in vulnerable hippocampal and cortical neurons, the work establishes a direct mechanistic link between general diabetic complications and cognitive decline, thereby bridging the related research fields
