SUSTAIN 5: As an add-on to basal insulin vs placebo 1,10 Study design: 30-week, randomized, double-blind, placebo-controlled, parallel-group, multinational, multicenter trial to compare the efficacy and safety of Ozempic injection in combination with basal insulin vs volume-matched placebo in combination with basal insulin
However, it is crucial to emphasise that GLP-1 medications should be discontinued before attempting conception following product-specific guidance, and any fertility benefits are likely mediated through weight loss and metabolic improvements rather than direct drug effects on reproductive organs
This section will summarize clinical safety findings on semaglutide and liraglutide, including common and serious side effects, safety considerations, and important precautions
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