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The GHRH pathway, mediated by the GHRH receptor (a class II G-protein coupled receptor), primarily couples to Gs proteins, activating adenylyl cyclase to increase intracellular cAMP levels

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Studies have demonstrated its capacity to modulate superoxide dismutase (SOD) activity and glutathione levels, positioning it as a compound of broad relevance across regenerative biology, dermatological research, and age-related tissue studies