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J Birjand Univ Med Sci

Supplementation strategies vary depending on the underlying cause of deficiency or risk factors: Oral supplements (typically 25-2000 micrograms daily) are suitable for individuals with adequate intrinsic factor production but insufficient dietary intake Sublingual or buccal preparations have no proven superiority over standard oral tablets at equivalent doses Intramuscular injections (usually 1000 micrograms of hydroxocobalamin) are the preferred treatment for pernicious anaemia and severe malabsorption

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Although danuglipron showed good weight loss in phase II trials, the drug was discontinued when a trial participant suffered liver damage

Since retatrutide may produce greater overall weight reduction, it could potentially lead to larger decreases in abdominal fat as well