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242 When GLP-1 binds to GLP-1R on -cells, it activates these cells and promotes the secretion of somatostatin

The DPP-4 inhibitor sitagliptin attenuates the progress of atherosclerosis in apolipoprotein-E-knockout mice via AMPK- and MAPK-dependent mechanisms

Going higher only makes sense if your weight loss has stalled at a lower dose and you are willing to accept more intense side effects for a relatively modest additional benefit

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