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It is especially concentrated in white blood cells and platelets, which release it at sites of injury to initiate the repair cascade
Therefore, a vegetarian, vegan, or restricted diet is a risk factor for B12 deficiency
High-dose oral B12 can still work for people who have mild absorption problems because a small amount is absorbed through passive diffusion, which is not affected by intrinsic factor
However, many people struggle to get enough vitamin B12 through diet alone, especially those who follow vegetarian or vegan diets, as plant-based foods generally lack the vitamin
The first decision is route of administration
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