Intranasal fosphenytoin: the promise of phosphate esters in nose-to-brain delivery of poorly soluble drugs
N.KotsiariA.SkuljecJ.et al
ACS Synth Biol 7(1):121131 Zanichelli F, Capasso S, Cipollaro M, Pagnotta E, Carten M, Casale F, Iori R, Galderisi U (2012) Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while at anti-cancer drug doses, it has a cytotoxic effect
In published studies, the fragment has not demonstrated meaningful impact on blood glucose, insulin sensitivity, or IGF-1 concentrations at research-relevant doses
IV has its place for clinical situations, but daily oral is his routine choice