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CHAC1-mediated GSH degradation in the matrix supports FeS cluster proteins and electron transport ( via two convergent mechanisms: the direct depletion of glutathione and the indirect facilitation of mitochondrial ROS production, thereby coupling sustained metabolic activity to ferroptotic cell death under cysteine limitation

10.1111/nyas.13407 110 Martel-PelletierJ.BarrA

FZD, Fuzi decoction

The mobility of the SNACs in the membrane clusters can then gradually lead to the peptide sinking into the membrane, as observed clearly in some of our unbiased simulations (see, e.g., Supplementary Video 11)

Compound: L-carnitine tartrate, acidity regulator citric acid