When kisspeptin signaling is disrupted, normal ovulatory function often breaks down with it
Based on the notion that phosphoinositide hydrolysis, pkc activity and GAP43 (substrate of PKC for neuronal growth) are involved in supporting neurite outgrowth, and the observation that neurite growth is inhibited by amitriptyline (Farbman et al., 1988), Wong et al

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It is not found in nature in its isolated form but is derived from a larger protective protein present in gastric secretions
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