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Rabbit studies of collagenase-induced osteoarthritis report that intra-articular AOD-9604 injections improved cartilage histology and reduced lameness, with the strongest effect when combined with hyaluronic acid

10.1186/s12883-020-01634-2 177

This peptide is the active ingredient in the topical copper peptides that have been sold as cosmetic agents on the dermatology shelf since the late 1980s, with the caveat being that topical GHK-Cu needs to penetrate the stratum corneum layer of skin before getting to the dermis, which houses the receptors for the peptide

Initial treatment often involves more frequent injections (weekly or biweekly), potentially transitioning to monthly maintenance as levels stabilise

Tirzepatide has three different dose floors