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A growing body of literature reports that turning on cell GLP-1 production potently improves islet function and glucose homeostasis (10, 16, 17, 24, 30, 31)
Discussion Summary of findings In the present study, we found that the risk of MOF was slightly lower, albeit not significantly, in those treated with GLP-1 RA compared to those treated with DPP-4is as add-on therapies to metformin
GLP-1 receptor agonists enhance beneficial bacterial strains, including Bifidobacterium and Lactobacillus, while diminishing harmful species such as Clostridium and Enterobacteriaceae (Singh et al
Furthermore, fibroblast growth factor 1 (FGF1) mitigates oxidative stress via the PI3K-AKT pathway, thereby slowing the progression of kidney injury in animal models, including the unilateral ureteral obstruction (UUO) and DN models [217]
And there may also be other lasting beneficial effects
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