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Discussion Our study establishes that non-gene-edited hCiPSC-NSCs, delivered via a dual-pathway strategy (intravenous systemic + intracerebroventricular boost), concurrently ameliorate ASD-like phenotypes in VPA-exposed rats by targeting the gut-brain axis

Maintenance sessions are often needed every few months

Prentki M, Peyot ML, Masiello P, Madiraju SRM

Evidence type: Human RCT | Observational

MAPK signaling, as one of the most prevalent pathways in plants, plays a crucial role in mediating tolerance mechanisms by functioning as a key component of signal transduction under abiotic and biotic stress conditions 170