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The depletion of GPX4 can increase the sensitivity of hepatocytes or cardiomyocytes to lipid peroxides, which can accelerate IRI-induced liver or cardiac injury [246,247,248]
Blockage of MTNR1B impairs melatonins ability to reduce cell proliferation and decrease TRIP13 To further confirm that MT exerts its effects through MTNR1B, cells were treated with MTNR1B inhibitor Luzindole [27], and we again performed the EdU assay to detect cell proliferation, but also added Luzindole