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Matrix of TME are also influenced by the consumption of glutamine leading to a decrease in energy supply required for T cells to perform immune functions, thereby suppressing their activity (266)

Together, these developments underscore the dynamic interplay between medical advances, social attitudes, and the lived experiences of individuals with obesity, highlighting the need for continued dialog around the ethical, cultural, and clinical implications of obesity treatment

It rapidly escalated into a global outbreak, leading the World Health Organization (WHO) to declare it a pandemic in March 2020

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