Individual variability in GLP-1 receptor sensitivity, peptide absorption, and metabolic pathways means some people respond strongly while others see minimal effects
Similarly, diet quality matters alongside medication
They're simple tests, they're inexpensive, they're not invasive, they're easy to do, and insurance usually covers them
In PCOS, where OS and IR intersect, MI supplementation restores downstream insulin sensitivity while attenuating ROS generation, a dual action that integrates metabolic correction with redox stabilization ( Experimental and clinical studies collectively reveal that MI modulates cellular redox balance by enhancing antioxidant enzyme activities and reducing oxidative biomarkers such as malondialdehyde (MDA) and nitric oxide derivatives (146, 149, 151)
The side effect profile is not trivial