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7 Emerging biomarkers and diagnostic approaches Recent multi-cohort studies show that the gut-immune-brain axis generates numerous biomarker classes including microbial, metabolic, inflammatory, and protein-seeding signatures that outperform single-modality diagnostic methods for PD

In diabetes, HG levels can trigger the expression of mesenchymal markers in RPE cells [60]

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A streamlined, patient-centered strategy balancing diagnostic thoroughness with timely interventions may aid clinicians in optimizing outcomes in this complex disease