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CHAC1-mediated GSH degradation reduces S-glutathionylation of ARF6 at cysteine 90, thereby inactivating ARF6 and enhancing ferroptotic cell death ( Similarly, CHAC1 is upregulated in various kidney disease models ( CHAC1 upregulation was induced by cysteine and methionine deprivation, treatment with erastin and exposure to tunicamycin

Ethics declarations Conflict of interest This research has no known conflict of financial interests or personal relationships that could have appeared to influence the work reported in this paper

doi: 10.1016/s0899-9007(00)00433-0