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Critical reconstitution rules When mixing your own semaglutide, these rules protect both accuracy and potency: Always swirl gently

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Participants with diabetes or active cardiovascular disease were excluded, as were those pregnant or with uncontrolled comorbidities

Never discontinue semaglutide abruptly without medical guidance, particularly if using it for diabetes management, as this could lead to deterioration in glycemic control

Cognitive behavioral therapy (CBT) remains the gold-standard psychological intervention, with evidence supporting its efficacy in reducing binge frequency and associated psychopathology