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In addition to GIPs role in promoting lipid storage in adipocytes 140 , the GIP receptor (GIPR) is found in neurons of the ARC, dorsomedial nucleus (DMH), and paraventricular nucleus of the hypothalamus 141

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These cytokines also downregulate GPX4, further sensitizing chondrocytes to ferroptosis

The receptor expression is lost in the corticotroph adenomas of patients with Cushings disease, which could be the potential mechanism of resistance to feedback of the HPA axis seen in these patients (212)

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