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This contractile event leads to opening of tight junction structures, as transmembrane tight junction proteins are linked to the PAMR through peripheral membrane proteins such as ZO-1 (45)

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All clinical investigations were conducted according to Declaration of Helsinki principles

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The combination is researched because of different receptor targets (activates both GHRH-R and GHSR pathways), synergistic effect (combined GH release may be 5-10x greater than either alone), complementary actions (CJC-1295 primes GH synthesis