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Furthermore, increased expression of hypoxia-inducible factor-2 (HIF-2), autophagy-related gene (ATG)-activated nuclear receptor coactivator 4 (NCOA4), and heme oxygenase 1 (HO-1) can regulate iron level changes in the body via the IRP pathway, ferritin autophagy, and senescent erythrocyte heme degradation (1921)