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doi: 10.3390/biomedicines9040419 73 CuiCWangXLianBJiQZhouLChiZet al

Given that SDH oxidizes succinate to fumarate while reducing CoQ 10 , one might predict that it functions similarly to other mitochondrial CoQ 10 oxidoreductases in suppressing ferroptosis by promoting ubiquinol (CoQ 10 H 2 ) production

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Additionally, extracellular succinate can be reuptake into cells, such as in brown adipose tissue under cold conditions, where it is taken up from the peripheral circulation and transported into mitochondria via SLC25A10 to participate in UCP1-dependent thermogenesis [77]

J Clin Immunol 2021;41:51525