La titulacin gradual de la dosis es necesaria para minimizar efectos secundarios
"Other side effects are possible, such as headaches or injection site reactions, since most GLP-1 agonists are taken as an injection," comments Mitri
Some side effects (like nausea) are dose-dependent and might be milder at low doses, but others, like how it blunts appetite, could still lead to inadequate nutrient intake or a loss of lean muscle mass (called sarcopenia) if someone is losing weight without proper diet management
However, activation of the afferent branch of the vagus nerve by capsaicin or activation of the vagus nerve and ENS by exendin-4, another GLP-1RA, failed to increase NE concentrations (Fig
The liver is most severely affected among them and histopathological findings of non-hepatic organs include decreased density of hematopoietic cells with increased nuclear debris in the bone marrow, increased apoptosis of the splenic lymphoid follicle, and degeneration/single cell necrosis of crypt epithelium of the small intestine (Figs
