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The full Thymosin Beta-4 molecule, under the name RGN-259, has entered formal clinical trials for conditions including dry eye disease and cardiac recovery, which validates the underlying biological mechanism that TB-500 shares

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Sleep 31(1):2133 Imeri L, Bianchi S, Opp MR (2005) Antagonism of corticotropin-releasing hormone alters serotonergic-induced changes in brain temperature, but not sleep, of rats