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More recent multicenter data ( n = 42, 2025) confirm doseresponse benefits and highlight early treatment ( C (p.Met340Thr) showed that riboflavin deficiency further reduced AIFM1 protein, while high-dose riboflavin partially reversed this loss and improved respiratory chain activity (53)

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Antenatal NAC administration was associated with changes in maternal and neonatal blood metabolomic signatures related to sulfur and nitric-oxide pathways