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Established programs and recommendations for when to screen and monitor women with obesity, diabetes, or incident GDM already exist, but action prior to pregnancy or periconceptional would be ideal (Tsakiridis et al
Insulin Sensitivity As estrogen levels fluctuate during perimenopause, many women become more insulin resistant, increasing the risk of type 2 diabetes and metabolic disorders
Add-ons Antioxidants like glutathione, amino acids like taurine and carnitine, fat-metabolism cofactors like MIC (methionine, inositol, choline), and specialty molecules like NAD+
Most options are either traditional OB/GYNs (who may not offer comprehensive hormone optimization) or wellness clinics (that lack medical depth)
For patients experiencing muscle discomfort or weakness while taking GLP-1 medications, several evidence-based strategies can help minimize symptoms while maintaining the therapeutic benefits of treatment
