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19 As local serum uric acid concentrations rise above their limit of solubility, monosodium urate can begin to precipitate out of the blood, forming needle-like crystals preferentially in cartilage and fibrous tissues

(Lausanne) 13 , 848715 (2022)

Rather than functioning as isolated antioxidant modules, these pathways form a highly interconnected redox buffering network in which compensatory capacity, metabolic flux, and iron availability collectively determine ferroptotic susceptibility

This might potentially lead to reduced infiltration of inflammatory cells in the lungs of mice with lung damage and lower levels of TNF-1 and IL-6 production to minimize damage

16 BorinM.SaracenoC.CataniaM.LorenzettoE.PontelliV.PaterliniA.et al (2018)