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The discontinuation rates due to adverse events, which were comparable to placebo, suggest that the transition to oral orforglipron is generally well-tolerated by patients already acclimated to incretin therapy

Although these studies failed to observe sickness upon activation of PPG neurons in the NTS in mice, a study in rat observed conditioned taste aversion upon injection of GLP1 into the central amygdala, but not into the paraventricular nucleus of the hypothalamus (Kinzig et al., 2003)

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