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The 10 mg dose of tirzepatide showed greater weight reduction versus semaglutide 1 mg by -1.8 mmHg (-3.4 to -0.1) while the 15 mg dose of tirzepatide reduced an additional -3 mmHg (-4.6 to -1.3) compared to semaglutide [65]

Out-of-Pocket Costs Drive Abandonment Especially in Obesity While payer restrictions and coverage gaps contribute to GLP-1 therapy abandonment, out-of-pocket (OOP) costs remain the most consistent and powerful predictor of non-adherence

Controls appetite

Side effects, dose and long-term safety vary for each drug

Retatrutide is more expensive in absolute terms but can deliver competitive or superior value per unit of outcome