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The animals were then dosed intravenously via the jugular vein catheters or intraperitoneally with dihexa dissolved in 75% DMSO

Applications in Animal Aging Models Animal aging models (such as naturally aged mice, D-galactose-induced aging mice, SAMP8 accelerated senescence mice, etc.) are core carriers for simulating human aging and verifying the efficacy of anti-aging drugs

B12 injections eliminate this absorption barrier entirely

It has two options: 3-monthly b12 injections or (often against clinician advice) no treatment

The closest human evidence in its drug class is Athira Pharma's fosgonimeton (ATH-1017), a structurally distinct molecule in the same HGF/c-Met program whose Phase 2/3 LIFT-AD Alzheimer's trial failed its primary endpoint in September 2024 (GST 0.08, P=.70)