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The primary endpoint for weight management is percent change in body weight, for OSA is change in ApneaHypopnea Index and for knee OA includes change in the Western Ontario and McMaster Universities Osteoarthritis Index pain subscale score
Mice deficient in aquaporin 7 have impaired glycerol release in response to fasting and treatment with beta-adrenergic agonists, although FA release from adipocytes and plasma FFA levels are comparable to those observed in wild-type littermates (75)
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It belongs to a novel class of agents known as triple agonists, targeting three incretin and metabolic receptors simultaneously: the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor
