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The results showed no significant differences between the Dula (150 g/kg) and SLZ groups, showing that the higher dosages of Dula (100 and 150 g/kg) were more efficient than the lower dosage (50 g/kg) at lowering the raised levels of TGF-1

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Liver problems: Liver injury has been reported in people who use kratom regularly, sometimes after months of use

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Administration of semaglutide at the dose regimen of ~ 90 g/kg/day failed to evidence significant weight loss but more importantly, led to alteration of cortical bone microarchitecture, represented by lower cortical thickness, and ultimately to a significant decrease in bone strength [69]