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Moreover, due to tumor heterogeneity, a biopsy from a single site may not represent the entire tumor's biological characteristics, potentially leading to misinterpretation of treatment responses, especially when tumor cells metastasize or develop drug resistance

doi: 10.1371/journal.pone.0196570 62 WalterUFranzkeASarukhanAZoberCvon BoehmerHBuerJet al